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Glymphatic System
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Recovery Failure in POTS, Long COVID, ME/CFS and Related Disorders: A Unified Biological Framework
Dr Graham Exelby 2026 Abstract Successful recovery following infection, injury and physiological stress requires coordinated resolution of inflammatory signalling, restoration of microvascular function, tissue repair and rebuilding of physiological reserve. Although persistent inflammation, endothelial dysfunction, mitochondrial abnormalities and chronic hypoxic signalling have each been implicated in Long COVID, postural orthostatic tachycardia syndrome (POTS), myalgic...
Graham Exelby
6 days ago
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:An Endothelial–Neurovascular Hypothesis of Brainstem Oxygen Homeostasis Failure
Dr Graham Exelby 2026 Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disorder characterised by post-exertional malaise (PEM), autonomic dysfunction, cognitive impairment, sleep disturbance and profound loss of functional capacity. Although abnormalities involving cerebral perfusion, endothelial function, neurovascular coupling, mitochondrial metabolism, immune activation and autonomic regulation have each been describ
Graham Exelby
Jul 5
Understanding Long COVID: How a Viral Illness Can Become a Disorder of Neurovascular Dysfunction, Impaired Recovery and Loss of Physiological Reserve
Dr Graham Exelby 2026 About This Paper This document is a simplified companion to a series of more detailed scientific papers exploring Long COVID, POTS, ME/CFS and related disorders. The formal papers examine the underlying biology in depth, including neurovascular dysfunction, pericyte biology, autonomic regulation, inflammatory signalling, metabolism, recovery physiology and the renin–angiotensin–aldosterone system (RAAS). While these concepts are important, the scientific
Graham Exelby
Jun 23
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