in preprint

in preprint

Simplified from “Gastroparesis in POTS and Long COVID: A Unified Hydraulic–Neuroimmune Model” by Dr Graham Exelby November 2025 Abstract Gastroparesis—delayed gastric emptying in the absence of obstruction—is common among patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Long COVID. Mounting evidence shows it to be a systemic, potentially reversible disorder driven by impaired venous return, lymphatic congestion, and neuro-immune-metabolic imbalance. In uprig

Dr Graham Exelby November 2025 Abstract Gastroparesis—delayed gastric emptying without mechanical obstruction—is increasingly observed in Postural Orthostatic Tachycardia Syndrome (POTS) and Long COVID, yet its mechanisms remain fragmented across vascular, metabolic, and neurogenic domains. We propose a unified hydraulic–neuroimmune model  integrating preload failure, lymphatic obstruction, microvascular hypoxia, and persistent viral neuroinflammation. Orthostatic preload fai

A Patient Guide to Understanding Mechanisms and Management Condensed and adapted from “ Reframing Postural Orthostatic Tachycardia Syndrome (POTS)-  as a Disorder of Preload Failure: Integrating Neurovascular and Immune Pathways ” by Dr Graham Exelby October 2025 What POTS Is and Why It Matters Postural Orthostatic Tachycardia Syndrome (POTS) is a condition of orthostatic intolerance—the body struggles to maintain blood flow to the brain when upright. Heart rate rises excessi

A Clinician Guide to Understanding Mechanisms and Management Condensed and adapted from “ Reframing Postural Orthostatic Tachycardia Syndrome (POTS)-  as a Disorder of Preload Failure: Integrating Neurovascular and Immune Pathways ” by Dr Graham Exelby October 2025 Abstract Postural Orthostatic Tachycardia Syndrome (POTS) is a disorder of orthostatic intolerance marked by excessive heart-rate increase upon standing, fatigue, cognitive fog, and visceral dysregulation. Emerging

Integrating Immune–Metabolic and Neurovascular Mechanisms in Long COVID and POTS: A Synthesis of Emerging Evidence and Clinical...

Dr Graham Exelby, September 2025 Extracted from “EBV Reactivation in Long COVID: A Mechanistic Synthesis,” September 2025...

Dr Graham Exelby October 2025. Simplified and condensed from: “Convergent Pathway Disruption in POTS, ME/CFS, and Long COVID: -A...

Dr Graham Exelby September 2025. This is a personal opinion and may differ from that of your medical advisers. Introduction Many centres...

Authors: Dr Graham Exelby, Ms Michelle Hille, certified Vodder Therapist.  September 2025 Executive Summary Sensitization explains why...

Simplified Overview condensed from Exelby & Hill, 2025,  “ Upright Head Pressure in Long COVID- from Acute Neurovascular Injury to...

Dr Graham Exelby, September 2025 A simplified an condensed version of “ Malignancy in the Post-COVID Terrain: A Systems Biology...

Dr Graham Exelby September 2025 Background : I have been involved in a long term longitudinal study of this problem, initially comparing...

Author:  Based on original work by Dr Graham Exelby, with contributions from Dr Valerio Vittone (PhD) Date: September 05, 2025 Purpose:...

Author:  Based on original work by Dr Graham Exelby Date:  September 05, 2025 Purpose:  This summary distils the complex role of...

Author:  Based on original work by Dr Graham Exelby, revised by Dr Valerio Vittone (PhD), reviewed by Dr Jonathon Jenkins Date:...

Author:  Based on original work by Dr Graham Exelby, with contributions from Dr Valerio Vittone (PhD) Date: September 05, 2025 Purpose:...

Author:  Based on original works by Dr Graham Exelby, Dr Valerio Vittone (PhD)   Date:  September 05, 2025 Purpose: This guide combines...

Results of supine and standing echocardiography Dr Graham Exelby August 2025 As we start seeing clear echocardiographic evidence of...