Mermaid Central Medical Clinic Research

Sharing research in Long COVID, POTS, fibromyalgia and other areas

Dr Graham Exelby December 2025- in peer review Preview: This diagram shows the root network of all chronic immunometabolic diseases: hypoxia HIF-1α → HIF-2α reprogramming ROS / RAGE / NF-κB activation STAT3–CCL2 macrophage/microglial loops NLRP3 inflammasome pericyte dropout BBB leak mast-cell activation mitochondrial failure / PDH shutdown glycolytic trap autonomic failure central sensitisation This is the “motherboard,” where from this “motherboard,” you can derive variants

Author: Dr Graham Exelby October 2025. A Reanalysis of: Exelby,G & Vittone,V.  DNA Mutations in POTS and Long COVID. 2023 (redacted), with translational assistance from Dr Valerio Vittone. Abstract Background: Dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), ME/CFS, Long COVID, vaccine injury, and malignancy have traditionally been considered distinct conditions. However, accumulating evidence suggests they share molecular drivers. Methods:   We conducted SNP-

Dr Graham Exelby, September 2025 Extracted from “EBV Reactivation in Long COVID: A Mechanistic Synthesis,” September 2025...

Dr Graham Exelby October 2025. Simplified and condensed from: “Genomic Redundancy as a Driver of Chronicity in POTS and Long COVID” Introduction Conditions like Postural Orthostatic Tachycardia Syndrome (POTS), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Long COVID affect many people with symptoms such as dizziness, fatigue, brain fog, palpitations, and post-exertional malaise (PEM, where even mild activity leads to a crash in energy). These conditions ca

Dr Graham Exelby September 2025. This is a personal opinion and may differ from that of your medical advisers. Introduction Many centres...