The Systemic Consequences of STAT3 Dysregulation in Long COVID:
A Unifying Molecular Pathway Across Malignancy, Autoimmunity, and Immune Dysregulation Dr Graham Exelby June 2025 Abstract: Long COVID is...
Graham Exelby
6 min read
Long COVID and Autism Spectrum Disorder- a Shared Pathophysiology-
The Role of the Malate-Aspartate Shuttle, Inflammation and Hypoxia Dr Graham Exelby June 2025 Abstract Long COVID and Autism Spectrum...
Graham Exelby
6 min read
Long COVID Progression- the Transitioning of Cytokine Dysregulation to Cellular Suicide
Dr Graham Exelby June 2025 Abstract Long COVID is emerging as a complex neuroimmune–metabolic disorder marked by persistent inflammation,...
Graham Exelby
9 min read
Extracellular Matrix Toxicity and Post-Exertional Malaise
- The Role of Fascial-Lymphatic Obstruction and Brainstem Hypoxia in Long COVID and POTS Dr Graham Exelby June 2025 Abstract: Emerging...
Graham Exelby
3 min read
Fascial-Lymphatic Obstruction and Brainstem Hypoxia in Long COVID and POTS
Dr Graham Exelby June 2025- a Preliminary paper Abstract: Emerging clinical observations suggest that post-exertional malaise (PEM) in...
Graham Exelby
2 min read
Origin of Brainstem Hypoperfusion in POTS and Long COVID: A Dual-Gate Hypothesis Linking Mechanical and Molecular Initiation
Dr. Graham Exelby June 2025- a Preliminary Paper Abstract Postural Orthostatic Tachycardia Syndrome (POTS) frequently presents after...
Graham Exelby
9 min read
Malignancy Risk in Long COVID
Overview for GPs Dr Graham Exelby June 2025 Overview: Emerging data and clinical experience suggest a potential increase in malignancy...
Graham Exelby
3 min read
POTS Comorbidities- by Functional Domain
Dr Graham Exelby May 2025 Abstract: This paper provides a structured overview of comorbid conditions observed in clinical POTS practice,...
Graham Exelby
5 min read
RAGE: A Central Amplifier in POTS
Dr Graham Exelby May 2025 Introduction Chronic hypoxia is a powerful initiator of immune dysregulation, neurovascular injury, and...
Graham Exelby
13 min read
POTS Activators – Clinical Overview with Mechanistic Insights
Dr Graham Exelby May 2025 Abstract Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a heterogenous dysautonomic condition...
Graham Exelby
8 min read
POTS Symptoms Overview
Dr Graham Exelby May 2025 Introduction Chronic multisystem conditions such as Postural Orthostatic Tachycardia Syndrome (POTS), Long...
Graham Exelby
7 min read
Telmisartan and Candesartan in Mitigating Cognitive Impairment in Long COVID
Dr Graham Exelby May 2024, revised May 2025 Abstract Angiotensin II receptor blockers (ARBs), particularly telmisartan and candesartan,...
Graham Exelby
13 min read
Lymphatic Obstruction in POTS, CFS, and Long COVID: A Call for Integrated Therapeutic Approaches
- Unblocking the Invisible Network: Fascia, Mast Cells, and the Clinical Relevance of Lymphatic Obstruction in Complex Syndromes Dr...
Graham Exelby
16 min read
Mast Cell Activation as a Driver of Central Sensitization in POTS, Long COVID, and Fibromyalgia
Mechanistic Hypotheses and the Role of Collagenase and RAGE Activation Dr Graham Exelby May 2025 Abstract Mast cell activation is...
Graham Exelby
9 min read
Neurovascular-Endocrine Dysfunction as a Core Axis in POTS, Long COVID, and Fibromyalgia
The interplay between intracranial venous congestion, brainstem hypoperfusion, and HPA axis dysfunction Dr Graham Exelby May 2025...
Graham Exelby
18 min read
Neurometabolic Modelling of PEM and Central Sensitisation
Dr Graham Exelby May 2025 Abstract Post-exertional malaise (PEM) and central sensitization are defining features of POTS, ME/CFS, Long...
Graham Exelby
10 min read
Mould, Sustained Stress, and PTSD Converge on the RAGE–TLR4 Axis: A Unifying Model of Neuroimmune Dysregulation
Dr Graham Exelby May 2025 Abstract Chronic mould exposure, sustained psychological stress, and PTSD have emerged as key environmental...
Graham Exelby
40 min read
Locus Coeruleus Hypoperfusion and Noradrenergic Vasospasm: A Central Mechanism in Dysautonomia and Cerebral Hypoperfusion
Dr Graham Exelby May 2025 Abstract Brainstem hypoperfusion is increasingly recognized as a unifying feature in dysautonomic syndromes...
Graham Exelby
17 min read
Intracranial Hypertension, Venous and Lymphatic Flow Dysfunction- the Core Hydraulic Dysfunctions
Dr Graham Exelby May 2025 Abstract Postural orthostatic tachycardia syndrome (POTS), particularly in the context of Long COVID, ME/CFS,...
Graham Exelby
56 min read
Hydraulic and Vascular Autonomic Dysregulation in POTS- The Modified Geddes Baroreceptor Hypothesis
Dr Graham Exelby May 2025 Abstract Postural Orthostatic Tachycardia Syndrome (POTS) reflects a multifactorial disruption of vascular,...
Graham Exelby
10 min read
