Mermaid Central Medical Clinic Research

Sharing research in Long COVID, POTS, fibromyalgia and other areas

Dr Graham Exelby 2026. Abstract The post-2020 rise in ADHD diagnoses, particularly among adolescents and young adults, coincides temporally with the COVID-19 pandemic and raises important questions regarding causality versus increased diagnostic awareness. This paper proposes an integrated physiological model in which SARS-CoV-2 infection acts as a systems-level stressor, unmasking or amplifying ADHD- and ASD-like phenotypes through disruption of preload-dependent cerebral pe

A personal update from Dr Graham Exelby June 2026 Over the past several years, what started as an attempt to better understand POTS has evolved into a much broader investigation of Long COVID, ME/CFS, Fibromyalgia, migraine, Ehlers-Danlos syndrome, chronic head pressure syndromes and related disorders. The more patients we studied, the clearer it became that many of these conditions may not be separate diseases at all. Instead, they appear to share common physiological pathwa

Dr Graham Exelby December 2025- in peer review Preview: This diagram shows the root network of all chronic immunometabolic diseases: hypoxia HIF-1α → HIF-2α reprogramming ROS / RAGE / NF-κB activation STAT3–CCL2 macrophage/microglial loops NLRP3 inflammasome pericyte dropout BBB leak mast-cell activation mitochondrial failure / PDH shutdown glycolytic trap autonomic failure central sensitisation This is the “motherboard,” where from this “motherboard,” you can derive variants

Author: Dr Graham Exelby October 2025. A Reanalysis of: Exelby,G & Vittone,V. DNA Mutations in POTS and Long COVID. 2023 (redacted), with translational assistance from Dr Valerio Vittone. Abstract Background: Dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), ME/CFS, Long COVID, vaccine injury, and malignancy have traditionally been considered distinct conditions. However, accumulating evidence suggests they share molecular drivers. Methods: We conducted SNP-

Dr Graham Exelby, September 2025 Extracted from “EBV Reactivation in Long COVID: A Mechanistic Synthesis,” September 2025...

Dr Graham Exelby October 2025. Simplified and condensed from: “Genomic Redundancy as a Driver of Chronicity in POTS and Long COVID” Introduction Conditions like Postural Orthostatic Tachycardia Syndrome (POTS), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Long COVID affect many people with symptoms such as dizziness, fatigue, brain fog, palpitations, and post-exertional malaise (PEM, where even mild activity leads to a crash in energy). These conditions ca

Dr Graham Exelby September 2025. This is a personal opinion and may differ from that of your medical advisers. Introduction Many centres...

Dr Graham Exelby September 2025 Background : I have been involved in a long term longitudinal study of this problem, initially comparing...

A Unifying Molecular Pathway Across Malignancy, Autoimmunity, and Immune Dysregulation Dr Graham Exelby June 2025- revised September 2025...

Dr Graham Exelby May 2025 Introduction Chronic hypoxia is a powerful initiator of immune dysregulation, neurovascular injury, and...

Dr Graham Exelby May 2025 Abstract Hypoxia-induced RAGE (Receptor for Advanced Glycation End Products) activation emerges as a unifying...

Your genetics determine if the body can clear toxins efficiently. Dr Valerio Vittone (PH.D) January 2023 Clearance of toxic compounds...

By Dr Valerio Vittone Screendumps from Dr Vittone's presentation at the MCAS Conference April 2023

Dr Graham Exelby Updated June 2026 As I pass more than fifty years in medicine, including over forty-five years in general practice, one lesson has remained constant: We never stop learning. Medicine continually reminds us that certainty is often temporary. What is accepted today may be revised tomorrow. The most important question I have learned to ask is not "What is the diagnosis?" but rather "Why is this happening?" That question has guided much of my professional life.