Mermaid Central Medical Clinic Research

Sharing research in Long COVID, POTS, fibromyalgia and other areas

Dr Graham Exelby December 2025- in peer review Preview: This diagram shows the root network of all chronic immunometabolic diseases: hypoxia HIF-1α → HIF-2α reprogramming ROS / RAGE / NF-κB activation STAT3–CCL2 macrophage/microglial loops NLRP3 inflammasome pericyte dropout BBB leak mast-cell activation mitochondrial failure / PDH shutdown glycolytic trap autonomic failure central sensitisation This is the “motherboard,” where from this “motherboard,” you can derive variants

Author: Dr Graham Exelby October 2025. A Reanalysis of: Exelby,G & Vittone,V.  DNA Mutations in POTS and Long COVID. 2023 (redacted), with translational assistance from Dr Valerio Vittone. Abstract Background: Dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), ME/CFS, Long COVID, vaccine injury, and malignancy have traditionally been considered distinct conditions. However, accumulating evidence suggests they share molecular drivers. Methods:   We conducted SNP-

Dr Graham Exelby, September 2025 Extracted from “EBV Reactivation in Long COVID: A Mechanistic Synthesis,” September 2025...

Dr Graham Exelby October 2025. Simplified and condensed from: “Genomic Redundancy as a Driver of Chronicity in POTS and Long COVID” Introduction Conditions like Postural Orthostatic Tachycardia Syndrome (POTS), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Long COVID affect many people with symptoms such as dizziness, fatigue, brain fog, palpitations, and post-exertional malaise (PEM, where even mild activity leads to a crash in energy). These conditions ca

Dr Graham Exelby September 2025. This is a personal opinion and may differ from that of your medical advisers. Introduction Many centres...

Dr Graham Exelby September 2025 Background : I have been involved in a long term longitudinal study of this problem, initially comparing...

Results of supine and standing echocardiography Dr Graham Exelby August 2025 As we start seeing clear echocardiographic evidence of...

A Unifying Molecular Pathway Across Malignancy, Autoimmunity, and Immune Dysregulation Dr Graham Exelby June 2025- revised September 2025...

Dr Graham Exelby May 2025 Abstract: This paper provides a structured overview of comorbid conditions observed in clinical POTS practice,...

Dr Graham Exelby May 2025 Introduction Chronic hypoxia is a powerful initiator of immune dysregulation, neurovascular injury, and...

- Unblocking the Invisible Network: Fascia, Mast Cells, and the Clinical Relevance of Lymphatic Obstruction in Complex Syndromes Dr...

Dr Graham Exelby May 2025 Abstract   Chronic mould exposure, sustained psychological stress, and PTSD have emerged as key environmental...

Dr Graham Exelby May 2025 Abstract Brainstem hypoperfusion is increasingly recognized as a unifying feature in dysautonomic syndromes...

Dr Graham Exelby May 2025 Abstract Postural Orthostatic Tachycardia Syndrome (POTS) reflects a multifactorial disruption of vascular,...

Dr Graham Exelby May 2025 Contents: 1.     Abstract 2.     Introduction 3.     Section 1- Linking Immune dysregulation to Metabolic,...

Dr Graham Exelby, with Deborah Calleja and Michelle Hill Abstract Postural Orthostatic Tachycardia Syndrome (POTS) is increasingly...

Dr Graham Exelby May 2025 with physiotherapy input from Stuart Stevenson Abstract This hypothesis paper presents the cardiac plexus—a...

Dr Graham Exelby May 2025 Abstract: Dysautonomia encompasses a diverse spectrum of syndromes marked by disordered autonomic nervous...

Dr Graham Exelby May 2025 Overview: Heart Rate Variability (HRV) reflects the dynamic interplay between the sympathetic and...

Dr Graham Exelby May 2025 Functional Continuum with Brainstem and Cardiac Plexus Involvement: Emerging evidence and clinical observation...