Understanding Recovery Failure in Long COVID, POTS, ME/CFS and Related DisordersA Patient Guide to Energy Production, Hypoxia and Recovery
Dr Graham Exelby June 2026 Introduction One of the most common questions asked by patients with Long COVID, POTS, ME/CFS and related disorders is: "Why am I not recovering?" Many patients describe a similar experience. Activities that were once effortless become exhausting. Physical activity, mental concentration, emotional stress, social interaction or even everyday tasks may trigger worsening symptoms. Recovery becomes slower, less predictable and increasingly incomplete.
Graham Exelby
7 min read
Hashimoto's Thyroiditis, Thyroid Nodules and Cervical Drainage DysfunctionA Neurovascular–Lymphatic Model of Thyroid Inflammatory Persistence
Dr Graham Exelby 2026 Abstract Hashimoto's thyroiditis and thyroid nodules are traditionally viewed as manifestations of autoimmune and endocrine disease arising from genetic susceptibility, environmental triggers, loss of immune tolerance, thyroid autoantibody production, and progressive glandular dysfunction. While these mechanisms remain central to disease pathogenesis, they incompletely incorporate the regional venous and lymphatic anatomy upon which normal thyroid physio
Graham Exelby
16 min read
Endometriosis as a Chronic HIF-2α-Dominant Hypoxia–Fibrosis Syndrome: A Unified Mechanistic Framework and Rationale for Metabolic Repurposing
Authors: Dr Graham Exelby1,2 & Dr Cris Beer1,3. 2025. 1MCMC-Research Collaborative, Gold Coast, Australia 2 University of Queensland School of Medicine (Adjunct), Brisbane 3Integrative Gynaecology & Women’s Health, Gold Coast Reviewed by Dr Valerio Vittone (PhD), Gold Coast Abstract Endometriosis is traditionally defined as ectopic endometrial-like tissue that evades immune clearance. Emerging molecular, vascular, and immunometabolic data suggest this view is incomplete. Evi
Graham Exelby
1 min read
From Genomic Redundancy to Physiological Network Fragility:A Systems-Level Model of Chronicity in POTS, Long COVID, and Related Neuroimmune Disorders
Dr Graham Exelby (2026) Systems-Level Insights Derived from Genomic Studies in POTS and Long COVID (2022–2026) with Dr Valerio Vittone Abstract Background POTS, Long COVID, ME/CFS, vaccine-associated syndromes, and connective tissue-associated neuroimmune disorders are traditionally approached as distinct clinical entities. However, increasing overlap in autonomic dysfunction, neurovascular abnormalities, inflammatory activation, connective tissue signatures, oxidative stress
Graham Exelby
2 min read
ADHD, Autism, and Neurodivergence After COVID-19:A Hypoxic–Neurovascular Model of Acquired Executive and Sensory Dysfunction
Dr Graham Exelby 2026. Abstract The post-2020 rise in ADHD diagnoses, particularly among adolescents and young adults, coincides temporally with the COVID-19 pandemic and raises important questions regarding causality versus increased diagnostic awareness. This paper proposes an integrated physiological model in which SARS-CoV-2 infection acts as a systems-level stressor, unmasking or amplifying ADHD- and ASD-like phenotypes through disruption of preload-dependent cerebral pe
Graham Exelby
2 min read
