

Origin of Brainstem Hypoperfusion in POTS and Long COVID: A Dual-Gate Hypothesis Linking Mechanical and Molecular Initiation
Dr. Graham Exelby June 2025- a Preliminary Paper Abstract Postural Orthostatic Tachycardia Syndrome (POTS) frequently presents after...
Graham Exelby
9 min read


POTS Symptoms Overview
Dr Graham Exelby May 2025 Introduction Chronic multisystem conditions such as Postural Orthostatic Tachycardia Syndrome (POTS), Long...
Graham Exelby
7 min read


GABA dysfunction in POTS, Long COVID, Fibromyalgia and Long COVID
Dr Graham Exelby December 2024 Abstract GABA (γ-aminobutyric acid), the primary inhibitory neurotransmitter in the central nervous...
Graham Exelby
13 min read
Heat and Cold Intolerance
Dr Graham Exelby December 2024 Temperature intolerance is a common symptom in Postural Orthostatic Tachycardia Syndrome (POTS) and often...
Graham Exelby
4 min read


Targeting the Perfect Storm- Amino Acid Dysfunction in Post Exertional Malaise-
Dr Graham Exelby. December 2024, revised February 2025 Introduction Post-exertional malaise (PEM) represents a multifactorial challenge...
Graham Exelby
25 min read


Brainstem Hypoperfusion, Coat hanger pain and Post-Exertional Malaise in POTS and Long COVID
Dr Graham Exelby September 2024 Brainstem hypoperfusion, coat hanger pain and PEM have similar pathogenesis, and are found in that same...
Graham Exelby
61 min read


Amino Acid, Essential Vitamin and Mineral Burn off in Post Exertional Malaise
A Preliminary Study -September 2024, currently being peer-reviewed Dr Graham Exelby Brainstem hypoperfusion, coat hanger pain and PEM...
Graham Exelby
62 min read


Breaking Through in POTS and Long Covid
Revised April 2025. Dr Graham Exelby We have moved away from the traditional model of treating POTS, CFS, Long COVID, and Fibromyalgia...
Graham Exelby
3 min read


Intra-Abdominal Vascular Compression Syndromes
Dr Graham Exelby January 2024 Looking closely at causes for autonomic dysfunction, there are quite a number of areas where compression of...
Graham Exelby
18 min read


Internal Jugular Vein Dysfunction- Jugular Outlet Syndrome, Internal Jugular Vein Stenosis and Obstruction
Dr Graham Exelby January 2024 Many of the typical symptoms associated with Postural Orthostatic Tachycardia Syndrome (POTS,)...
Graham Exelby
39 min read


The Glymphatic System
Glymphatic System (or glymphatic clearance pathway or paravascular system) Dr Graham Exelby. January 2024- Currently under revision...
Graham Exelby
33 min read


Cervical Spine Abnormality, Ehlers-Danlos Syndrome and Vertebral Vascular and Lymphatic Dysfunction
Dr Graham Exelby December 2023 This section is currently being revised to incorporate evolving information about the newly discovered CSF...
Graham Exelby
50 min read
Low Glutamate Diet
December 2023 Dr Graham Exelby, Dr Valerio Vittone, Ms Kelley Bright Diet change can be extremely important managing the inflammatory...
Graham Exelby
6 min read


Managing POTS
May 2024 Dr Graham Exelby Currently under review and peer review to accommodate new findings, and will be incorporated into the...
Graham Exelby
44 min read


DNA Mutations in POTS and Long Covid-Practitioner version MCAS Conference- April 2 2023-
By Dr Valerio Vittone Screendumps from Dr Vittone's presentation at the MCAS Conference April 2023
Graham Exelby
1 min read


DNA Mutations in POTS and Long Covid- Patient version-MCAS Conference- April 2 2023
by Dr Valerio Vittone These are "screendumps" of the patient presentation by Dr Vittone at the MCAS Conference April 2023. I apologize...
Graham Exelby
1 min read


Nicotinamide Mononucleotide (NMN)
Dr Graham Exelby May 2024 Currently being revised to incorporate the use of nicotinamide in amino acid dysfunction Nicotinamide...
Graham Exelby
8 min read
Low Dose Naltrexone, Ketotifen and other Mast Cell Treatments
Dr Graham Exelby May 2024 This is part of a personal management protocol in POTS, Long Covid and other MCAS-associated conditions. There...
Graham Exelby
12 min read


Thoracic Outlet Syndrome (incorporating Costoclavicular Syndrome)
Dr Graham Exelby revised December 2023 Acknowledgment: this article has been produced with a large contribution by Kjetil Larsen. His...
Graham Exelby
24 min read


































