Mermaid Central Medical Clinic Research

Sharing research in Long COVID, POTS, fibromyalgia and other areas

An Integrated Neurovascular, Cranial Hydraulic and Sensory-Gating Model Graham Exelby Abstract Visual snow syndrome (VSS) is a neurological disorder characterised by the continuous perception of fine dynamic visual static across the visual field, commonly accompanied by palinopsia, photophobia, nyctalopia, enhanced entoptic phenomena, tinnitus and migraine.[1–4] Contemporary neuroimaging and electrophysiological studies support dysfunction extending beyond the primary visual

Dr Graham Exelby May 2026 Abstract Background Postural Orthostatic Tachycardia Syndrome (POTS) and Long COVID frequently demonstrate abnormalities of the renin–angiotensin–aldosterone system (RAAS), yet the physiological significance of these findings remains poorly understood. Conventional endocrine testing protocols were developed primarily to identify primary aldosteronism and do not adequately assess dynamic neurovascular control responses during orthostatic stress. Incre

Christopher Thomas, BScApp. MScSt. AMS. DMU, Dr Graham Exelby , MBBS February 2026 Abstract Background: Postural orthostatic tachycardia syndrome (POTS), Long COVID–associated dysautonomia, and post-vaccine syndromes are typically defined by heart-rate responses and autonomic testing, with limited direct assessment of preload or forward flow. Emerging population-level data identify an orthostatic cardiac output–fall phenotype characterised by stroke-volume reduction despite p

An Integrated Hydraulic–Neurovascular Framework Linking the Brain, Neck and Body Cranial Venous Drainage, Cavernous Sinus Physiology, Neurovascular Adaptation and the Distinct Mechanisms of Upright and Supine Head Pressure Dr Graham Exelby July 2026 Executive Statement Many patients present with overlapping symptoms—including head pressure, migraine, dizziness, pulsatile tinnitus, retro-orbital pain, visual disturbance, coathanger pain, brain fog and orthostatic intolerance

Dr Graham Exelby 2026 Abstract Successful recovery following infection, injury and physiological stress requires coordinated resolution of inflammatory signalling, restoration of microvascular function, tissue repair and rebuilding of physiological reserve. Although persistent inflammation, endothelial dysfunction, mitochondrial abnormalities and chronic hypoxic signalling have each been implicated in Long COVID, postural orthostatic tachycardia syndrome (POTS), myalgic...

Dr Graham Exelby 2026 Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disorder characterised by post-exertional malaise (PEM), autonomic dysfunction, cognitive impairment, sleep disturbance and profound loss of functional capacity. Although abnormalities involving cerebral perfusion, endothelial function, neurovascular coupling, mitochondrial metabolism, immune activation and autonomic regulation have each been describ

Authors: Dr Graham Exelby1,2 & Dr Cris Beer1,3. 2025. 1MCMC-Research Collaborative, Gold Coast, Australia 2 University of Queensland School of Medicine (Adjunct), Brisbane 3Integrative Gynaecology & Women’s Health, Gold Coast Reviewed by Dr Valerio Vittone (PhD), Gold Coast Abstract Endometriosis is traditionally defined as ectopic endometrial-like tissue that evades immune clearance. Emerging molecular, vascular, and immunometabolic data suggest this view is incomplete. Evi

Dr Graham Exelby (2026) Systems-Level Insights Derived from Genomic Studies in POTS and Long COVID (2022–2026) with Dr Valerio Vittone Abstract Background POTS, Long COVID, ME/CFS, vaccine-associated syndromes, and connective tissue-associated neuroimmune disorders are traditionally approached as distinct clinical entities. However, increasing overlap in autonomic dysfunction, neurovascular abnormalities, inflammatory activation, connective tissue signatures, oxidative stress

Dr Graham Exelby 2026. Abstract The post-2020 rise in ADHD diagnoses, particularly among adolescents and young adults, coincides temporally with the COVID-19 pandemic and raises important questions regarding causality versus increased diagnostic awareness. This paper proposes an integrated physiological model in which SARS-CoV-2 infection acts as a systems-level stressor, unmasking or amplifying ADHD- and ASD-like phenotypes through disruption of preload-dependent cerebral pe