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  • Writer's pictureGraham Exelby

Fibromyalgia Syndrome and the Linking with POTS and Chronic Fatigue Syndrome-References

1.     Overlapping Conditions. American Myalgia Encephalomyelitis and Chronic Fatigue Syndrome Society.

2.     Clauw DJ. Fibromyalgia: more than just a musculoskeletal disease. Am Fam Physician. 1995 Sep 1;52(3):843-51, 853-4. Erratum in: Am Fam Physician 1996 Nov 1;54(6):1896, 1901-2. PMID: 7653424.

3.     Boomershine,C. Fibromyalgia. 2023. Medscape.

4.     Fibromyalgia. National Institute of Arthritis and Musculoskeletal and Skin Diseases.

5.     Bragée B, Michos A, Drum B, Fahlgren M, Szulkin R, Bertilson BC. Signs of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Front Neurol. 2020 Aug 28;11:828. doi: 10.3389/fneur.2020.00828. PMID: 32982905; PMCID: PMC7485557.

6.     Hulens M, Dankaerts W, Rasschaert R, Bruyninckx F, De Mulder P, Bervoets C. The Link Between Empty Sella Syndrome, Fibromyalgia, and Chronic Fatigue Syndrome: The Role of Increased Cerebrospinal Fluid Pressure. J Pain Res. 2023;16:205-219

7.     Raj SR, Fedorowski A, Sheldon RS. Diagnosis and management of postural orthostatic tachycardia syndrome. CMAJ. 2022 Mar 14;194(10):E378-E385. doi: 10.1503/cmaj.211373. PMID: 35288409; PMCID: PMC8920526.

8.     Gemignani F, Melpignano A, Milioli G, Riccardi S, Parrino L. Restless legs syndrome: a new entity of neuropathic pain? Treatment with prolonged release oxycodone/naloxone combination. Research and Reviews in Parkinsonism. 2016;6:23-27

9.     María Toriello, PhD, Vicente González-Quintanilla, PhD, Sara Pérez-Pereda, MD, Noelia Fontanillas, PhD, Julio Pascual, PhD, The Potential Role of the Glymphatic System in Headache Disorders, Pain Medicine, Volume 22, Issue 12, December 2021, Pages 3098–3100,

10.  Wei, Y., Liang, Y., Lin, H. et al. Autonomic nervous system and inflammation interaction in endometriosis-associated pain. J Neuroinflammation 17, 80 (2020).

11.  Clough E, Inigo J, Chandra D, Chaves L, Reynolds JL, Aalinkeel R, Schwartz SA, Khmaladze A, Mahajan SD. Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID. J Neuroimmune Pharmacol. 2021 Dec;16(4):770-784. doi: 10.1007/s11481-021-10015-6. Epub 2021 Oct 2. Erratum in: J Neuroimmune Pharmacol. 2021 Dec 11;: PMID: 34599743; PMCID: PMC8487226.

12.  Garland EF, Hartnell IJ, Boche D. Microglia and Astrocyte Function and Communication: What Do We Know in Humans? Front Neurosci. 2022 Feb 16;16:824888. doi: 10.3389/fnins.2022.824888. PMID: 35250459; PMCID: PMC8888691.

13.  ANS Balance Assessment.  Bioscan Medeia Inc.

14.  Afrin, Lawrence; Weinstock, Leonard; Molderings, Gerhard. Covid-19 Hyperinflammation and post-Covid 19 may be rooted in Mast Cell Activation Syndrome. 2020: International Journal of Infectious Diseases 100, 327-332.

15.  Weinstock,L., et al, Mast cell activation symptoms are prevalent in Long-COVID, 2021. International Journal of Infectious Diseases 112 (2021) 217-226 

16.  Gunning WT 3rd, Kvale H, Kramer PM, Karabin BL, Grubb BP. Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies. J Am Heart Assoc. 2019 Sep 17;8(18):e013602. doi: 10.1161/JAHA.119.013602. Epub 2019 Sep 9. PMID: 31495251; PMCID: PMC6818019.

18.  Li L, Acioglu C, Heary RF, Elkabes S. Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases. Brain Behav Immun. 2021 doi: 10.1016/j.bbi.2020.10.007.

19.  Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010 Nov 11;468(7321):232-43. doi: 10.1038/nature09613. PMID: 21068832; PMCID: PMC3206737.

20.  Zhang,P et al. Enhanced Glial Reaction and Altered Neuronal Nitric Oxide Synthase are Implicated in Attention Deficit Hyperactivity Disorder. Front. Cell Dev. Biol, 2022.

21.  Afrin, L. Presentation,Diagnosis and Management of Mast Cell Activation Syndrome. 2013. Nova Science Publishers,Inc.

22.  Goldenberg DL. Could Long COVID Research Lead to Breakthroughs in Fibromyalgia and Chronic Fatigue? Practical Pain Manag. 2022.

23.  Raj V, Haman KL, Raj SR, Byrne D, Blakely RD, Biaggioni I, Robertson D, Shelton RC. Psychiatric profile and attention deficits in postural tachycardia syndrome. J Neurol Neurosurg Psychiatry. 2009 Mar;80(3):339-44. doi: 10.1136/jnnp.2008.144360. Epub 2008 Oct 31. PMID: 18977825; PMCID: PMC2758320.

24.  Bashir ST, Redden CR, Raj K, Arcanjo RB, Stasiak S, Li Q, Steelman AJ, Nowak RA. Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis. J Neuroinflammation. 2023 Mar 6;20(1):59. doi: 10.1186/s12974-023-02713-0. PMID: 36879305; PMCID: PMC9987089.

25.  Conti,P, Gallenga,C, Caraffa,A, Ronconi,G, Kritas,S. Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role? Dermatologic Therapy. 2019.

26.  Carthy, Elliott & Ellender, Tommas. (2021). Histamine, Neuroinflammation and Neurodevelopment: A Review. Frontiers in Neuroscience. 15. 10.3389/fnins.2021.680214.

27.  Alim MA, Grujic M, Ackerman PW, Kristiansson P, Eliasson P, Peterson M, Pejler G. Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells. Cell Mol Immunol. 2021 Oct;18(10):2383-2392. doi: 10.1038/s41423-020-0421-z. Epub 2020 Apr 20. Erratum in: Cell Mol Immunol. 2020 Sep 3;: PMID: 32313211; PMCID: PMC8484602.

28.  Theoharides TC, Tsilioni I, Bawazeer M. Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. Front Cell Neurosci. 2019 Aug 2;13:353. doi: 10.3389/fncel.2019.00353. PMID: 31427928; PMCID: PMC6687840.

29.  Xie Y, Xu E, Bowe B, et al. Long-term cardiovascular outcomes of COVID-19. Nat Med 2022.

30.     Dong H, Zhang X, Wang Y, Zhou X, Qian Y, Zhang S. Suppression of Brain Mast Cells Degranulation Inhibits Microglial Activation and Central Nervous System Inflammation. Mol Neurobiol. 2017 Mar;54(2):997-1007. doi: 10.1007/s12035-016-9720-x. Epub 2016 Jan 21. PMID: 26797518 

31.  Low, J et al. Neuropathology of COVID-19 (neuro-COVID): clinicopathological update. Free Neuropathol. 2021 January 18; 2: . doi:10.17879/freeneuropathology-2021-2993.

32.  Wood PB, Schweinhardt P, Jaeger E, Dagher A, Hakyemez H, Rabiner EA, Bushnell MC, Chizh BA. Fibromyalgia patients show an abnormal dopamine response to pain. Eur J Neurosci. 2007 Jun;25(12):3576-82. doi: 10.1111/j.1460-9568.2007.05623.x. PMID: 17610577.

33.  Becker S, Schweinhardt P. Dysfunctional neurotransmitter systems in fibromyalgia, their role in central stress circuitry and pharmacological actions on these systems. Pain Res Treat. 2012;2012:741746. doi: 10.1155/2012/741746. Epub 2011 Oct 2. PMID: 22110944; PMCID: PMC3195783.

35.  Heath E, Chieng B, Christie MJ, Balleine BW. Substance P and dopamine interact to modulate the distribution of delta-opioid receptors on cholinergic interneurons in the striatum. Eur J Neurosci. 2018 May;47(10):1159-1173. doi: 10.1111/ejn.13750. Epub 2017 Nov 14. PMID: 29055101.

36.  Guy-Evans, O. (2021, Sept 27). Hypothalamic-Pituitary-Adrenal Axis. Simply Psychology.–pituitary–adrenal-axis.html

37.  Katz DL, Greene L, Ali A, Faridi Z. The pain of fibromyalgia syndrome is due to muscle hypoperfusion induced by regional vasomotor dysregulation. Med Hypotheses. 2007;69(3):517-25. doi: 10.1016/j.mehy.2005.10.037. Epub 2007 Mar 21. PMID: 17376601.

38.  Bsibsi M, Persoon-Deen C, Verwer RW, Meeuwsen S, Ravid R, Van Noort JM. Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators. Glia. 2006 May;53(7):688-95. doi: 10.1002/glia.20328. PMID: 16482523.

39.  Bakker ENTP, Naessens DMP, VanBavel E. Paravascular spaces: entry to or exit from the brain? Exp Physiol. 2019 Jul;104(7):1013-1017. doi: 10.1113/EP087424. Epub 2019 Jan 9. PMID: 30582766; PMCID: PMC6618149.

40.  Oya M, Matsuoka K, Kubota M, Fujino J, Tei S, Takahata K, Tagai K, Yamamoto Y, Shimada H, Seki C, Itahashi T, Aoki YY, Ohta H, Hashimoto RI, Sugihara G, Obata T, Zhang MR, Suhara T, Nakamura M, Kato N, Takado Y, Takahashi H, Higuchi M. Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism. Sci Rep. 2023 Jul 19;13(1):11655. doi: 10.1038/s41598-023-38306-3. PMID: 37468523; PMCID: PMC10356952.

41.  Gzielo,K, Nikiforuk,A. Astroglia in Autism Spectrum Disorder. International Journal of Molecular Sciences. 2021.

42.  Allen, M., Huang, B.S., Notaras, M.J. et al. Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling. Mol Psychiatry 27, 2470–2484 (2022).

43.  Verger, A., Kas, A., Dudouet, P. et al. Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience. Eur J Nucl Med Mol Imaging 49, 3197–3202 (2022).

44.  Hotowitz,T, Pellurin,L, Zimmer, E, Guedj,E. Brain fog in long COVID: A glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism. Elsevier, Medical Hypotheses.

45.  Langan, M.T., Kirkland, A.E., Rice, L.C. et al. Low glutamate diet improves working memory and contributes to altering BOLD response and functional connectivity within working memory networks in Gulf War Illness. Sci Rep 12, 18004 (2022).

46.  Brandley,E, Kirkland, A, Baron,M, Baraniuk, J, Holton,K. The Effect of the Low Glutamate Diet on the Reduction of Psychaitric Symptoms in Veterans with Gulf War Illness: A Pilot Randomized-Controlled Trial. Front. Psychiatry. 2022.

47.  Romanos J, Benke D, Pietrobon D, Zeilhofer HU, Santello M. Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine. Sci Adv. 2020 Jun 5;6(23):eaaz1584. doi: 10.1126/sciadv.aaz1584. PMID: 32548257; PMCID: PMC7274778.

48.  Mogensen, F.L.-H.; Delle, C.; Nedergaard, M. The Glymphatic System (En)during Inflammation. Int. J. Mol. Sci. 2021, 22, 7491.

49.  Humm AM, Bostock H, Troller R, Z'Graggen WJ. Muscle ischaemia in patients with orthostatic hypotension assessed by velocity recovery cycles. J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1394-8. doi: 10.1136/jnnp-2011-300444. Epub 2011 Jun 7. PMID: 21653205.

50.  Khurana RK. Coat-hanger ache in orthostatic hypotension. Cephalalgia. 2012;32(10):731-737. doi:10.1177/0333102412449932

51.  Coat Hanger Pain as a Symptom across Conditions.

52.  Wirth, K.J., Scheibenbogen, C. & Paul, F. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021).

53.  Appelman, B., Charlton, B.T., Goulding, R.P. et al. Muscle abnormalities worsen after post-exertional malaise in long COVID. Nat Commun 15, 17 (2024).

54.  Morris, L, Charnet,D, Murrough,J, McGall, J. The role of the locus coeruleus in the generation of pathological anxiety. Brain and Neuroscience Advances. 2020 DOI:10.1177/2398212820930321

55.  Higgins N, Pickard J, Lever A. Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study. JRSM Short Rep. 2013 Nov 21;4(12):2042533313507920. doi: 10.1177/2042533313507920. PMID: 24475346; PMCID: PMC3899735.

56.  Higgins JNP, Pickard JD, Lever AML. Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure? Med Hypotheses. 2017 Aug;105:6-9. doi: 10.1016/j.mehy.2017.06.014. Epub 2017 Jun 24.

57.  Higgins N, Pickard J, Lever A. Borderline Intracranial Hypertension Manifesting as Chronic Fatigue Syndrome Treated by Venous Sinus Stenting. J Neurol Surg Rep. 2015 Nov;76(2):e244-7. doi: 10.1055/s-0035-1564060. Epub 2015 Sep 14.

58.  Jenssen,N et al. The Glymphatic System- A Beginners’s Guide. Neurochem Res. 2015 December ; 40(12): 2583–2599. doi:10.1007/s11064-015-1581-6.

59.  Townsend RK, Fargen KM. Intracranial Venous Hypertension and Venous Sinus Stenting in the Modern Management of Idiopathic Intracranial Hypertension. Life (Basel). 2021 May 31;11(6):508. doi: 10.3390/life11060508. PMID: 34073077; PMCID: PMC8227267.

60.  Higgins JN et al. Headache, cerebrospinal fluid leaks, and pseudomeningoceles after resection of vestibular schwannomas: efficacy of venous sinus stenting suggests cranial venous outflow compromise as a unifying pathophysiological mechanism. J Neurol Surg B. DOI: 10.1055/s-0039-1677706

61.  Perez MA, Bialer OY, Bruce BB, Newman NJ, Biousse V. Primary Spontaneous Cerebrospinal Fluid Leaks and Idiopathic Intracranial Hypertension. Journal of Neuro-Ophthalmology 2013;33:330–337doi: 10.1097/WNO.0b013e318299c292

62.  Alkhotani A. Cerebrospinal Fluid Rhinorrhea Secondary to Idiopathic Intracranial Hypertension. Case Rep Neurol 2019;11:295–298

63.  Bidot S, Levy JM, Saindane AM, Oyesiku NM, Newman NJ, Biousse V. Do Most Patients With a Spontaneous Cerebrospinal Fluid Leak Have Idiopathic Intracranial Hypertension? Official Journal of the North American Neuro-ophthalmology Society, 01 Dec 2019, 39(4):487-495 DOI: 10.1097/wno.0000000000000761

64.  Mokri,B. Intracranial Hypertension After Treatment of Spontaneous Cerebrospinal Fluid Leaks. Mayo Clin Proc. 2002;77:1241-1246

65.  Pasumarthi, Anusha MSc; Luo, Annette BS; Shah, Hemali BS, BA; Carroll, Ian MD, MS. Letter: Considering Cerebrospinal Fluid Leaks in Ehlers-Danlos Patients: Raising Awareness Amongst Neurosurgeons

66.  Russek LN, Block NP, Byrne E, Chalela S, Chan C, Comerford M, Frost N, Hennessey S, McCarthy A, Nicholson LL, Parry J, Simmonds J, Stott PJ, Thomas L, Treleaven J, Wagner W and Hakim A (2023) Presentation and physical therapy management of upper cervical instability in patients with symptomatic generalized joint hypermobility: International expert consensus recommendations. Front. Med. 9:1072764. doi: 10.3389/fmed.2022.1072764

67.  Swyden,S, Carter,C, Shah,S. Intracranial Hypotension. StatPearls. 2023.

68.  Morris G, Maes M. Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways. Metab Brain Dis. 2014 Mar;29(1):19-36. doi: 10.1007/s11011-013-9435-x. Epub 2013 Sep 10. PMID: 24557875.

70.  Barnden,L.MRI Data reports significant differences between ME/CFS and HC for connectivity within the brainstem. National Centre for Neuroimmunology and Emerging Diseases - NCNED 2019.

71.  Barnden L, Shan Z, Staines D, Marshall-Gradisnik S, Finegan K, Ireland T, Bhuta S. Intra brainstem connectivity is impaired in chronic fatigue syndrome. Neuroimage Clin. 2019;24:102045. doi: 10.1016/j.nicl.2019.102045. Epub 2019 Oct 19. PMID: 31671321; PMCID: PMC6835065.

72.  Geddes JR, Ottesen JT, Mehlsen J, Olufsen MS. Postural orthostatic tachycardia syndrome explained using a baroreflex response model. J R Soc Interface. 2022 Aug;19(193):20220220. doi: 10.1098/rsif.2022.0220. Epub 2022 Aug 24. PMID: 36000360; PMCID: PMC9399868.

73.  Bombardieri AM, Albers GW, Rodriguez S, et al. Percutaneous cervical sympathetic block to treat cerebral vasospasm and delayed cerebral ischemia: a review of the evidence. Journal of NeuroInterventional Surgery  2022. doi: 10.1136/jnis-2022-019838

74.  Jacob, L., Boisserand, L.S.B., Geraldo, L.H.M. et al. Anatomy and function of the vertebral column lymphatic network in mice. Nat Commun 10, 4594 (2019).

75.  Albayram, M.S., Smith, G., Tufan, F. et al. Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes. Nat Commun 13, 203 (2022).

76.  Wells,R, Malik,V.,Lau,D. et al, : Cerebral Blood Flow and Cognitive Performance in Postural Tachycardia Syndrome: Insights from Sustained Cognitive Stress Test. Journal of the American Heart Association, 2020. doi: 10.1161/JAHA.120.017861. Epub 2020 Dec 5. PMID: 33280488; PMCID: PMC7955388.

77.  Van Campen, C.; Rowe, P.C.; Visser, F.C. Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Medicina 2022, 58, 28.

78.  Sonkaya,S, Öztrk B, Karadaş Ö. Cerebral hemodynamic alterations in patients with Covid-19. Turk J Med Sci. 2021 Apr 30;51(2):435-439. doi: 10.3906/sag-2006-203. PMID: 33021761; PMCID: PMC8203147

79.  van Campen C, Verheugt F, Rowe PC et al (2020) Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: a quantitative, controlled study using Doppler echography. ClinNeurophysPract  2020. doi: 10.1016/j.cnp.2020.01.003. PMID: 32140630; PMCID: PMC7044650.

80.  van Campen CLMC, Rowe PC, Visser FC. Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome). J Transl Med. 2021 doi: 10.1186/s12967-021-02819-0. PMID: 33947430; PMCID: PMC8097965.

81.  Hira, R et al. Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19. 2022. Canadian Journal of Cardiology. DOI:

82.  Katz EA, Katz SB, Fedorchuk CA, Lightstone DF, Banach CJ, Podoll JD. Increase in cerebral blood flow indicated by increased cerebral arterial area and pixel intensity on brain magnetic resonance angiogram following correction of cervical lordosis. Brain Circ 2019;5:19-26.

83.  Bulut,M et al. Decreased Vertebral Artery Hemodynamics in Patients with Loss of Cervical Lordosis. 2016. Med Sci Monit; 22:495-500

84.  Ogoh,S., Tarumi, T. Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function. 2019. The Journal of Physiological Sciences.

85.  Hoffham,R, Stiller,R. Resolution of Obstructive Sleep Apnea after Microvascular Brainstem Decompression. 1995. Chest Journal.

86.  Filchenko,I et al. Brainstem Strokes with Increased Obstructive Apnea Index during Sleep acutely after stroke. European Respiratory Journal 2021. DOI: 10.1183/13993003.congress-2021.PA943

87.  Brown DL, McDermott M, Mowla A, De Lott L, Morgenstern LB, Kerber KA, Hegeman G 3rd, Smith MA, Garcia NM, Chervin RD, Lisabeth LD. Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med. 2014 Aug;15(8):887-91. doi: 10.1016/j.sleep.2014.04.003. Epub 2014 May 2. PMID: 24916097; PMCID: PMC411773

88.  Ioachim, G et al. Altered Pain in the Brainstem and Spinal Cord of Fibromyalgia Patients During the Anticipation and Experience of Experimental Pain. Front. Neurol., 06 May 2022.

89.  Mello-Carapes,P, Izquierdo,I. The Nucleus of the Solitary Tract → Nucleus Paragigantocellularis → Locus Coeruleus → CA1 region of dorsal hippocampus pathway is important for consolidation of object recognition memory. Neurobiology of Learning and Memory. 2013.

90.  Natale,G et al. Glymphatic System as a Gateway to Connect Neurodegeneration from Periphery to CNS. 2021. Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS. Front. Neurosci. 15:639140. doi: 10.3389/fnins.2021.639140

91.  Sullan MJ, Asken BM, Jaffee MS, DeKosky ST, Bauer RM. Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy. Neurosci Biobehav Rev. 2018 Jan;84:316-324. doi: 10.1016/j.neubiorev.2017.08.016. Epub 2017 Aug 30. PMID: 28859995.

92.  Cant,R, Dalgleish,A, Allen,R. Naltrexone Inhibits IL-6 and TNFα Production in Human Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors. Front. Immun ol. 2017.

94.  Tooba R, Mayuga KA, Wilson R, Tonelli AR. Dyspnea in Chronic Low Ventricular Preload States. Ann Am Thorac Soc. 2021 Apr;18(4):573-581. doi: 10.1513/AnnalsATS.202005-581CME. PMID: 33792518; PMCID: PMC8009011.

95.  Tewfik,T. Thoracic Duct Anatomy.

96.  Joseph P, Singh I, Oliveira R, Capone CA, Mullen MP, Cook DB, Stovall MC, Squires J, Madsen K, Waxman AB, Systrom DM. Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not? Chest. 2023 Sep;164(3):717-726. doi: 10.1016/j.chest.2023.03.049. Epub 2023 Apr 11. PMID: 37054777; PMCID: PMC10088277.

98.  Gustavo A. Reyes del PasoAna M. Contreras-MerinoPablo de la CobaStefan Duschek. The cardiac, vasomotor, and myocardial branches of the baroreflex in fibromyalgia: Associations with pain, affective impairments, sleep problems, and fatigue. Psychophysiology 2021.

99.  Ana M. Contreras-Merino, Dmitry M. Davydov, Carmen M. Galvez-Sánchez, Gustavo A. Reyes del Paso. Blunted short-term autonomic cardiovascular reactivity to orthostatic and clinostatic challenges in fibromyalgia as an indicator of the severity of chronic pain. International Journal of Psychophysiology. 2022.

100.                De Silva, M.,The costoclavicular syndrome: a 'new cause'.Ann Rheum Dis. 1986 Nov; 45(11): 916–920.

101.                Blitshteyn, S., Whitelaw,S.” Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID‑19 infection: a case series of 20 patients. 2021. Immunologic Research

102.                  Marshall-Gradisnik et al. Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients. Immunology and Immunogenetics Insights 2015:7 1–6 doi:10.4137/III.S25147.

103. Eaton‑Fitch et al.  Impaired TRPM3‑dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients Journal of Translational Medicine‑022‑03297‑8

104. Cabanas, H., Muraki, K., Eaton, N. et al. Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Mol Med 24, 44 (2018)

105.                  Marshall-Gradisnik,Sonya, Eaton-Fitch,Natalie. Understanding myalgic encephalitis. 2022. Science. DOI: 10.1126/science.abo1261.

106.                  Bonaz,B., Sinniger,V., Pellisier,,S.: Vagal Tone: Effects on Sensitivity, Motility and Inflammation. Neurogastroenterol. Motil. 2016 Apr;28(4):455-62.

107.                  Wikipedia. Vagal Tone

108.                  Wikipedia. Baroreflex.

109.                Yang H, George SJ, Thompson D, Silverman HA, Tsaava T, Tynan A, Pavlov VA, Chang E, Andersson U, Brines M, Chavan SS, Tracey KJ. Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm. 2022 Mol Med. doi: 10.21203/

110.                  Prandoni P et al. Prevalence of pulmonary embolism among patients hospitalized for syncope. N Engl J Med 2016 Oct 20; 375:1524.

  1. Illig,k., Doyle, A.: A Comprehensive Review of Paget-Schroetter Syndrome, Journal of Vascular Surgery, Volume 51, Issue 6, June 2010,

  2. PFO Research Foundation:

113.                  Bashashati,M.,Moradi, M., Sarosiek,I.: Interleukin-6 in irritable bowel syndrome: A systematic review and meta-analysis of IL-6 (-G174C) and circulating IL-6 levels. Cytokine. 2017 Nov;99:132-138. doi: 10.1016/j.cyto.2017.08.017. Epub 2017 Sep 5.

114.                  Karantanos,T., Markoutsaki,T., Gazouli,M., Anagnou, N., Karamanolius,D. Current insights in to the pathophysiology of Irritable Bowel Syndrome Gut Pathog. 2010; 2: 3.

115.                  Margaret M. Leach, Craig Phillips, David Joffe, Charles Fisher, Michael Appleberg, Michael Jones, John E. Kellow, Irritable Bowel Syndrome Patients Exhibit Post-Prandial Autonomic Dysfunction. Gastroenterology.

116.                  Liu, l., Liu, B., Chen,S., Wang, M., Liu, Y., Zhang, Y, Yao, S. Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low- grade inflammation in a subset of irritable bowel syndrome patients Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2014 15(10):907-914

117.                  Patel S, Singh AMisra VMisra, S, Dwivedi MTrivedi P. Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome. Indian J Pathol Microbiol. 2017 Jul-Sep;60(3):385-389.

118.                  Coss-Adame, E., Rao, S.  Brain and Gut Interactions in Irritable Bowel Syndrome: New Paradigms and New Understandings  Curr Gastroenterol Rep. 2014 April ; 16(4): 379. doi:10.1007/s11894-014-0379-z.

119.                  Vittone,V.: Epigenetics.

120.                  Freed, D. Do dietary lectins cause disease? BMJ. 1999; 31: 1023-4

121.                  Baldwin AL. Mast cell activation by stress. Methods Mol Biol. 2006;315:349-60. doi: 10.1385/1-59259-967-2:349. PMID: 16110169.

122.                  Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Raikwar SP, Iyer SS, Bhagavan SM, Beladakere-Ramaswamy S, Zaheer A. Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis. Front Neurosci. 2017 Dec 12;11:703. doi: 10.3389/fnins.2017.00703. PMID: 29302258; PMCID: PMC5733004.

123.                Gunning WT 3rd, Kvale H, Kramer PM, Karabin BL, Grubb BP. Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies. J Am Heart Assoc. 2019 Sep 17;8(18):e013602. doi: 10.1161/JAHA.119.013602. Epub 2019 Sep 9. PMID: 31495251; PMCID: PMC6818019.

124.                Rs4680. SNPedia.

125.                Van der Knaap LJ, Schaefer JM, Franken IH, Verhulst FC, van Oort FV, Riese H. Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. Genes Brain Behav. 2014 Sep;13(7):618-25. doi: 10.1111/gbb.12147. Epub 2014 Jun 24. PMID: 24902721. 

126.                Song J, da Costa KA, Fischer LM, et al. Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J. 2005;19(10):1266-1271. doi:10.1096/fj.04-3580com

127.                Collister,J., Liu, X, Clifton,L. Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists. 2022. Front. Genet.,,genome%2C%20each%20of%20which%20can

128.                Pham MH, Bonello GB, Castiblanco J, Le T, Sigala J, He W, Mummidi S. The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance. PLoS One. 2012;7(11):e49498. doi: 10.1371/journal.pone.0049498. Epub 2012 Nov 16. PMID: 23166687; PMCID: PMC3500309

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