Dr Graham Exelby 2026 About This Paper This document is a simplified companion to a series of more detailed scientific papers exploring Long COVID, POTS, ME/CFS and related disorders. The formal papers examine the underlying biology in depth, including neurovascular dysfunction, pericyte biology, autonomic regulation, inflammatory signalling, metabolism, recovery physiology and the renin–angiotensin–aldosterone system (RAAS). While these concepts are important, the scientific

Dr Graham Exelby June 2026 Introduction One of the most common questions asked by patients with Long COVID, POTS, ME/CFS and related disorders is: "Why am I not recovering?" Many patients describe a similar experience. Activities that were once effortless become exhausting. Physical activity, mental concentration, emotional stress, social interaction or even everyday tasks may trigger worsening symptoms. Recovery becomes slower, less predictable and increasingly incomplete.

Dr Graham Exelby 2026 Abstract Hashimoto's thyroiditis and thyroid nodules are traditionally viewed as manifestations of autoimmune and endocrine disease arising from genetic susceptibility, environmental triggers, loss of immune tolerance, thyroid autoantibody production, and progressive glandular dysfunction. While these mechanisms remain central to disease pathogenesis, they incompletely incorporate the regional venous and lymphatic anatomy upon which normal thyroid physio

Authors: Dr Graham Exelby1,2 & Dr Cris Beer1,3. 2025. 1MCMC-Research Collaborative, Gold Coast, Australia 2 University of Queensland School of Medicine (Adjunct), Brisbane 3Integrative Gynaecology & Women’s Health, Gold Coast Reviewed by Dr Valerio Vittone (PhD), Gold Coast Abstract Endometriosis is traditionally defined as ectopic endometrial-like tissue that evades immune clearance. Emerging molecular, vascular, and immunometabolic data suggest this view is incomplete. Evi

Dr Graham Exelby (2026) Systems-Level Insights Derived from Genomic Studies in POTS and Long COVID (2022–2026) with Dr Valerio Vittone Abstract Background POTS, Long COVID, ME/CFS, vaccine-associated syndromes, and connective tissue-associated neuroimmune disorders are traditionally approached as distinct clinical entities. However, increasing overlap in autonomic dysfunction, neurovascular abnormalities, inflammatory activation, connective tissue signatures, oxidative stress

Dr Graham Exelby 2026. Abstract The post-2020 rise in ADHD diagnoses, particularly among adolescents and young adults, coincides temporally with the COVID-19 pandemic and raises important questions regarding causality versus increased diagnostic awareness. This paper proposes an integrated physiological model in which SARS-CoV-2 infection acts as a systems-level stressor, unmasking or amplifying ADHD- and ASD-like phenotypes through disruption of preload-dependent cerebral pe

A personal update from Dr Graham Exelby June 2026 Over the past several years, what started as an attempt to better understand POTS has evolved into a much broader investigation of Long COVID, ME/CFS, Fibromyalgia, migraine, Ehlers-Danlos syndrome, chronic head pressure syndromes and related disorders. The more patients we studied, the clearer it became that many of these conditions may not be separate diseases at all. Instead, they appear to share common physiological pathwa

Dr Graham Exelby December 2025- in peer review Preview: This diagram shows the root network of all chronic immunometabolic diseases: hypoxia HIF-1α → HIF-2α reprogramming ROS / RAGE / NF-κB activation STAT3–CCL2 macrophage/microglial loops NLRP3 inflammasome pericyte dropout BBB leak mast-cell activation mitochondrial failure / PDH shutdown glycolytic trap autonomic failure central sensitisation This is the “motherboard,” where from this “motherboard,” you can derive variants

Dr Graham Exelby, September 2025 Extracted from “EBV Reactivation in Long COVID: A Mechanistic Synthesis,” September 2025...

Dr Graham Exelby September 2025. This is a personal opinion and may differ from that of your medical advisers. Introduction Many centres...

Dr Graham Exelby September 2025 Background : I have been involved in a long term longitudinal study of this problem, initially comparing...

A Unifying Molecular Pathway Across Malignancy, Autoimmunity, and Immune Dysregulation Dr Graham Exelby June 2025- revised September 2025...

Dr Graham Exelby May 2025 Introduction Chronic hypoxia is a powerful initiator of immune dysregulation, neurovascular injury, and...

Dr Graham Exelby May 2025 Abstract Hypoxia-induced RAGE (Receptor for Advanced Glycation End Products) activation emerges as a unifying...

Your genetics determine if the body can clear toxins efficiently. Dr Valerio Vittone (PH.D) January 2023 Clearance of toxic compounds...

By Dr Valerio Vittone Screendumps from Dr Vittone's presentation at the MCAS Conference April 2023

Dr Graham Exelby Updated June 2026 As I pass more than fifty years in medicine, including over forty-five years in general practice, one lesson has remained constant: We never stop learning. Medicine continually reminds us that certainty is often temporary. What is accepted today may be revised tomorrow. The most important question I have learned to ask is not "What is the diagnosis?" but rather "Why is this happening?" That question has guided much of my professional life.