Intracranial Hypertension, Venous and Lymphatic Flow Dysfunction- the Core Hydraulic Dysfunctions
Dr Graham Exelby May 2025 Abstract Postural orthostatic tachycardia syndrome (POTS), particularly in the context of Long COVID, ME/CFS,...
Graham Exelby
56 min read
Hydraulic and Vascular Autonomic Dysregulation in POTS- The Modified Geddes Baroreceptor Hypothesis
Dr Graham Exelby May 2025 Abstract Postural Orthostatic Tachycardia Syndrome (POTS) reflects a multifactorial disruption of vascular,...
Graham Exelby
10 min read
Dysautonomia as a Neuroimmune–Metabolic Disorder: A Unified Model Linking TLR4 Activation, Brainstem Hypoxia, and Autonomic Plexus Dysfunction
Dr Graham Exelby May 2025 Contents: 1. Abstract 2. Introduction 3. Section 1- Linking Immune dysregulation to Metabolic,...
Graham Exelby
30 min read
Coeliac Plexus in POTS : Insights into MALS, SMA and Nutcracker Syndrome in POTS
Dr Graham Exelby, with Deborah Calleja and Michelle Hill Abstract Postural Orthostatic Tachycardia Syndrome (POTS) is increasingly...
Graham Exelby
19 min read
Cardiac Plexus in POTS- a Central Node in POTS Pathophysiology
Dr Graham Exelby May 2025 with physiotherapy input from Stuart Stevenson Abstract This hypothesis paper presents the cardiac plexus—a...
Graham Exelby
18 min read
Preload Dysfunction in POTS and ME/CFS: The Azygous System, Autonomic Plexii, and Inflammatory Pathways
Dr Graham Exelby May 2025 Abstract This paper investigates the pivotal but underrecognized role of the azygous venous system in preload...
Graham Exelby
22 min read
Autonomic Dysregulation: A Systems-Level Integration of Brainstem Hypoperfusion, Plexus Dysfunction, and Immune-Metabolic Crosstalk in Dysautonomia
Dr Graham Exelby May 2025 Abstract: Dysautonomia encompasses a diverse spectrum of syndromes marked by disordered autonomic nervous...
Graham Exelby
16 min read
Amino Acid Neurotransmitter Dysfunction as a Central Driver of Mitochondrial Failure and Autonomic Instability in POTS, CFS/ME, Long COVID and Gulf War Syndrome
Dr Graham Exelby May 2025 Abstract Amino acid neurotransmitter dysfunction—specifically involving glutamate, GABA, and aspartate—emerges...
Graham Exelby
5 min read
Dysautonomia in Clinical Practice
Dr Graham Exelby May 2025 Introduction Dysautonomia refers to a range of conditions caused by dysfunction in the autonomic nervous system...
Graham Exelby
21 min read
Heart Rate Variability (HRV) in Autonomic Assessment
Dr Graham Exelby May 2025 Overview: Heart Rate Variability (HRV) reflects the dynamic interplay between the sympathetic and...
Graham Exelby
2 min read
Long COVID Investigations
This is a personal methodology in Long COVID and similar in POTS A Clinical Guide for GPs Dr Graham Exelby May 2025 Checklist: 1. ...
Graham Exelby
4 min read
Thoracic Outlet Syndrome, Abdominal Vascular Compression Syndromes and the Functional Continuum in Dysautonomia
Dr Graham Exelby May 2025 Functional Continuum with Brainstem and Cardiac Plexus Involvement: Emerging evidence and clinical observation...
Graham Exelby
4 min read
RAGE–TLR4–NF-κB–CCL2 Looping Activation in Long COVID and Sensitization Syndromes
Dr Graham Exelby May 2025 Overview: In Long COVID, POTS, and ME/CFS, chronic inflammation is sustained not by acute infection, but by...
Graham Exelby
2 min read
QT Prolongation in COVID and Long COVID
Dr Graham Exelby May 2025 Overview: QT prolongation reflects delayed myocardial repolarization and increases the risk of ventricular...
Graham Exelby
2 min read
POTS Management in General Practice
Clinical Overview and Treatment Protocol for GPs Dr Graham Exelby May 2025 Overview: Postural Orthostatic Tachycardia Syndrome (POTS) is...
Graham Exelby
2 min read
Malignancy Risk in Long COVID
Dr Graham Exelby May 2025 Overview: Emerging data suggest a potential increase in malignancy risk following SARS-CoV-2 infection. This...
Graham Exelby
2 min read
Intracranial Fluid Dynamics and Structural Influences
Dr Graham Exelby May 2025 This section is to summary the hydraulic changes seen in POTS and Long COVID Venous (and Arterial)...
Graham Exelby
1 min read
Integrated Immune and Metabolic Dysfunction in POTS and Long COVID
Mechanistic Framework for Clinical Understanding Dr Graham Exelby May 2025 Overview: POTS and Long COVID share a complex clinical...
Graham Exelby
2 min read
Hypoxia-Driven RAGE Activation: A Core Pathophysiology
Dr Graham Exelby May 2025 Abstract Hypoxia-induced RAGE (Receptor for Advanced Glycation End Products) activation emerges as a unifying...
Graham Exelby
19 min read
Beyond the Symptoms: Targeting Underlying Mechanisms in POTS
Dr Graham Exelby April 2025 Table of Contents 1. Introduction: A Shift Toward Root-Cause POTS Management 2. Hypoxia as the Common...
Graham Exelby
12 min read
