Beyond the Symptoms: Targeting Underlying Mechanisms in POTS
Dr Graham Exelby April 2025 Table of Contents 1. Introduction: A Shift Toward Root-Cause POTS Management 2. Hypoxia as the Common...
Graham Exelby
12 min read


Brainstem Hypoperfusion in POTS,CFS, Fibromyalgia, Long COVID and GWS -a Key Role
Dr Graham Exelby May 2025 Abstract Brainstem hypoperfusion represents a unifying and upstream pathophysiological mechanism in postural...
Graham Exelby
24 min read
POTS Part 2 Pathophysiology
The Unifying Hypotheses to understand the processes Driving POTS, how hypoxia, neuroimmune Dysregulation and Autonomic Dysfunction in...
Graham Exelby
5 min read
POTS Part 5 Comorbidities
Dr Graham Exelby March 2025 Introduction to POTS Comorbidities Postural Orthostatic Tachycardia Syndrome (POTS) exists not as an isolated...
Graham Exelby
2 min read
POTS Part 4 Symptoms
Dr Graham Exelby March 2025 Introduction Postural Orthostatic Tachycardia Syndrome (POTS) can be conceptualized as a disorder of...
Graham Exelby
1 min read
POTS Part 3 Activators
Dr Graham Exelby March 2025 Abstract Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a heterogenous dysautonomic...
Graham Exelby
3 min read
POTS Part 1: Epidemiology and Overview
Dr Graham Exelby March 2025 Part of major review of POTS based on causes, drivers demonstrating the linking between inflammation, immune...
Graham Exelby
2 min read


GABA dysfunction in POTS, Long COVID, Fibromyalgia and Long COVID
Dr Graham Exelby December 2024 Abstract GABA (γ-aminobutyric acid), the primary inhibitory neurotransmitter in the central nervous...
Graham Exelby
13 min read
Heat and Cold Intolerance
Dr Graham Exelby December 2024 Temperature intolerance is a common symptom in Postural Orthostatic Tachycardia Syndrome (POTS) and often...
Graham Exelby
4 min read


Targeting the Perfect Storm- Amino Acid Dysfunction in Post Exertional Malaise-
Dr Graham Exelby. December 2024, revised February 2025 Introduction Post-exertional malaise (PEM) represents a multifactorial challenge...
Graham Exelby
25 min read


Brainstem Hypoperfusion, Coat hanger pain and Post-Exertional Malaise in POTS and Long COVID
Dr Graham Exelby September 2024 Brainstem hypoperfusion, coat hanger pain and PEM have similar pathogenesis, and are found in that same...
Graham Exelby
61 min read


Amino Acid, Essential Vitamin and Mineral Burn off in Post Exertional Malaise
A Preliminary Study -September 2024, currently being peer-reviewed Dr Graham Exelby Brainstem hypoperfusion, coat hanger pain and PEM...
Graham Exelby
62 min read
The Genetic Basis to Improving Toxin Detoxification
Your genetics determine if the body can clear toxins efficiently. Dr Valerio Vittone (PH.D) January 2023 Clearance of toxic compounds...
Graham Exelby
7 min read


Breaking Through in POTS and Long Covid
Revised April 2025. Dr Graham Exelby We have moved away from the traditional model of treating POTS, CFS, Long COVID, and Fibromyalgia...
Graham Exelby
3 min read


Intra-Abdominal Vascular Compression Syndromes
Dr Graham Exelby January 2024 Looking closely at causes for autonomic dysfunction, there are quite a number of areas where compression of...
Graham Exelby
18 min read


Internal Jugular Vein Dysfunction- Jugular Outlet Syndrome, Internal Jugular Vein Stenosis and Obstruction
Dr Graham Exelby January 2024 Many of the typical symptoms associated with Postural Orthostatic Tachycardia Syndrome (POTS,)...
Graham Exelby
39 min read


The Glymphatic System
Glymphatic System (or glymphatic clearance pathway or paravascular system) Dr Graham Exelby. January 2024- Currently under revision...
Graham Exelby
33 min read


Cervical Spine Abnormality, Ehlers-Danlos Syndrome and Vertebral Vascular and Lymphatic Dysfunction
Dr Graham Exelby December 2023 This section is currently being revised to incorporate evolving information about the newly discovered CSF...
Graham Exelby
50 min read
Low Glutamate Diet
December 2023 Dr Graham Exelby, Dr Valerio Vittone, Ms Kelley Bright Diet change can be extremely important managing the inflammatory...
Graham Exelby
6 min read


Managing POTS
May 2024 Dr Graham Exelby Currently under review and peer review to accommodate new findings, and will be incorporated into the...
Graham Exelby
44 min read






























